Ukushintsha Imibono Yabathengi Ekugugeni

Izimo zengqondo zabathengi ngokuguga ziyathuthuka. Ngokombiko wezitayela zabathengi ngoUmthengi OmushafuthiI-Coefficient Capital, abantu baseMelika abengeziwe abagxili nje ekuphileni isikhathi eside kodwa nasekuphileni ukuphila okunempilo.

Inhlolovo yango-2024 kaMcKinsey yembula ukuthi ngonyaka odlule, u-70% wabathengi e-US nase-UK (kanye no-85% e-China) bathenge imikhiqizo namasevisi engeziwe asekela ukuguga okunempilo nokuphila isikhathi eside uma kuqhathaniswa neminyaka edlule. Lolu shintsho lubonisa isifiso esikhulayo sabathengi sokuthatha ukulawula okukhulu empilweni yabo.

Ngaphezu kwalokho,I-Nutrition Business Journal's(I-NBJ) I-2024 Longevity Report ikhombisa ukuthi kusukela ngo-2022, ukukhula kokuthengisa esigabeni sokuguga okunempilo bekulokhu kuyidlula imakethe yezithako ezibanzi. Ngo-2023, imboni yezithako zokudla iyonke ikhule ngo-4.4%, kanti isigaba sokuguga esinempilo sithole izinga lokukhula elingu-5.5%.I-NBJamaphrojekthi ukuthi yokuthengisa ofizithako zokuguga ezinempilo- ehlanganisa izigaba ezihlukene ezibhekene nezimo ezithile - izodlula i- $ 1 billion ngo-2024 futhi ifinyelele ku- $ 1.04 billion ngo-2026, emele izinga lokukhula lika-7.7%.
1.Ukukhathazeka Kwabathengi Mayelana Nezindaba Zezempilo Ezihlobene Nobudala

AnI-NBJinhlolovo eyenziwe ngo-2024 yahlola ukukhathazeka kwabathengi okuhlobene nokuguga. Izinkinga ezibalulekile zifakiwe:

Ukulahleka kokuhamba (28%)
Isifo se-Alzheimer noma ukuwohloka komqondo (23%)
Ukulahleka kombono (23%)
Ukulahlekelwa ukuzimela (19%)
Izinselele zempilo yemizwa noma yengqondo (19%)
Ukuwohloka kwemisipha noma kwamathambo (19%)
Ukuqothuka kwezinwele (16%)
Ukuqwasha (16%)

Umthombo wesithombe: NBJ

Uma usebenzisaizithako, ukungatheleleki (35%) kuvele njengokukhathazeka kwezempilo okuhlobene neminyaka kubathengi. Ezinye izinto eziza kuqala zihlanganisa impilo yamathumbu kanye nempilo yokugaya (28%), impilo yokulala (23%), izinwele, isikhumba, nezinzipho (22%), impilo yemisipha nempilo ehlangene (21%), impilo yenhliziyo (19%), kanye nempilo engokomzwelo (19%).

Umthombo wesithombe: NBJ

2.Izithako Ezinhlanu Ezibalulekile Zokulwa Nokuguga

1. Ergothioneine

I-Ergothioneine iyi-amino acid eyenzeka ngokwemvelo eyatholwa ngo-1909 nguCharles Tanret ngenkathi efunda isikhunta se-ergot. I-thiol yayo ehlukile kanye ne-thione tautomerism ku-pH ye-physiological iyinikeza izakhiwo ze-antioxidant ezingavamile. Ngokusho kwedatha evela ku-Bloomage Biotech, i-ergothioneine ku-Bioyouth™-EGT ibonisa umsebenzi wokulahla wamahhala we-DPPH izikhathi ezingu-14 kune-glutathione kanye nezikhathi ezingu-30 kune-coenzyme Q10.

Izinzuzo:

Isikhumba:I-Ergothioneine ivikela ukuvuvukala okubangelwa yi-UV, ivimbela ukulimala kwe-DNA, futhi ikhuthaza ukuhlanganiswa kwe-collagen ngenkathi yehlisa ukuwohloka kwe-collagen ehlobene ne-UV.
Ubuchopho:I-Ergothioneine isekela ukusebenza kwengqondo, njengoba kuboniswa ucwaningo lomtholampilo olubonisa ukuqonda okuthuthukisiwe ngemva kwamasonto angu-12 okungeziwe nge-ergothioneine etholakala ngamakhowe.
Lala:Yeqa umgoqo wegazi-ubuchopho, inciphisa ukwakheka kwe-peroxynitrite, futhi inciphise ukucindezeleka, ikhuthaze ukulala okungcono.

2. I-Spermidine

I-Spermidine, ingxenye yomndeni we-polyamine, itholakala kakhulu ezintweni eziphilayo ezinjengamagciwane, isikhunta, izitshalo nezilwane. Imithombo yokudla evamile ihlanganisa igciwane likakolweni, ubhontshisi wesoya, namakhowe enkosi oyster. Amazinga e-Spermidine ehla ngokukhula, futhi imiphumela yawo yokulwa nokuguga ibangelwa izindlela ezifana nokungeniswa kwe-autophagy, umsebenzi wokulwa nokuvuvukala, nokulawulwa kwe-lipid metabolism.

Izindlela:

I-Autophagy:I-Spermidine ikhuthaza izinqubo zokuvuselela amaselula, ukubhekana nezifo ezihlobene neminyaka ehlobene nokukhubazeka kwe-autophagy.
I-anti-inflammatory: Inciphisa ama-cytokines ane-pro-inflammatory ngenkathi ikhulisa izici ezilwa nokuvuvukala.
I-Lipid Metabolism:I-Spermidine ithonya kahle ukwakheka kwe-lipid nokugcinwa, isekela ulwelwesi lwamangqamuzana olwelwesi lweselula kanye nokuphila isikhathi eside.

3. I-Pyrroloquinoline Quinone (PQQ)

I-PQQ, i-quinone coenzyme encibilika emanzini, ibalulekile ekusebenzeni kwe-mitochondrial. Ivikela emonakalweni we-mitochondrial obangelwa ukucindezeleka oxidative, ikhuthaza i-mitochondrial biogenesis, futhi ithuthukise ukukhiqizwa kwe-nerve growth factor (NGF). Ucwaningo lwezokwelapha lubonisa ukusebenza kahle kwayo ekuthuthukiseni ukusebenza kwengqondo kanye nokugeleza kwegazi kwesifunda kubantu asebekhulile.

4. I-Phosphatidylserine (PS)

I-PS iyi-anionic phospholipid kulwelwesi lwamaseli eukaryotic, ibalulekile ezinqubweni ezifana nokusebenza kwe-enzyme, i-cell apoptosis, nomsebenzi we-synaptic. Isuselwe emithonjeni efana nobhontshisi wesoya, izinto eziphilayo zasolwandle, nobhekilanga, i-PS isekela amasistimu e-neurotransmitter, afaka i-acetylcholine ne-dopamine, axhunywe nempilo yengqondo.

Izinhlelo zokusebenza:Ukwengezwa kwe-PS kuxhunyaniswe nokuthuthukiswa kwezimo ezifana ne-Alzheimer's, isifo sika-Parkinson, kanye nokudangala, futhi kuzuzisa abantu abane-ADHD kanye ne-autism spectrum disorders.

5. Urolithin A(UA)

I-UA, i-metabolite ye-ellagitannins etholakala ekudleni okufana namapomegranati nama-walnuts, yatholakala ngo-2005. Ucwaningo olushicilelwe ku-Umuthi Wemvelo(2016) ibonise ukuthi i-UA ikhuthaza i-mitophagy, yelula isikhathi sokuphila se-nematode ngama-45%. Ivula imizila ye-autophagy ye-mitochondrial, isuse i-mitochondria eyonakele futhi ibhekane nokungasebenzi kahle okuhlobene neminyaka emisipha, yenhliziyo, yomzimba, kanye nempilo yesikhumba.

I-UA yenziwe yasebenza i-mitophagy pathway/Inkomba yomthombo wesithombe 1

Isiphetho

Njengoba abathengi ngokuya bebeka eqhulwini impilo nokuphila isikhathi eside, isidingo sezithako ezintsha zokulwa nokuguga siyaqhubeka sikhula. Izithako ezibalulekile ezifana ne-ergothioneine, i-spermidine, i-PQQ, i-PS, ne-UA zivula indlela yezixazululo ezihlosiwe zokukhathazeka okuhlobene nobudala. Lezi zinhlanganisela ezisekelwe ngokwesayensi zigcizelela ukuzibophezela kwemboni ekusekeleni ukuguga okunempilo, okunamandla.