Ukushintsha Imibono Yabathengi Ngokuguga

Izimo zengqondo zabathengi ngokuguga ziyashintsha. Ngokusho kombiko wemikhuba yabathengi ka-Umthengi OmushafuthiI-Coefficient Capital, abantu baseMelika abaningi abagxili nje ekuphileni isikhathi eside kodwa nasekuphileni impilo enempilo.

Ucwaningo lukaMcKinsey lwango-2024 lwembula ukuthi ngonyaka odlule, ama-70% abathengi e-US nase-UK (kanye nama-85% eShayina) bathenge imikhiqizo nezinsizakalo eziningi ezisekela ukuguga okunempilo nokuphila isikhathi eside uma kuqhathaniswa neminyaka edlule. Lolu shintsho lubonisa isifiso esikhulayo sabathengi sokuthatha ukulawula okukhulu empilweni yabo.

Ngaphezu kwalokho,Ijenali Yebhizinisi Lokudla Okunempilo(I-NBJ) Umbiko Wokuphila Isikhathi Eside Ka-2024 ukhombisa ukuthi kusukela ngo-2022, ukukhula kokuthengisa esigabeni sokuguga okunempilo kuye kwadlula njalo imakethe ebanzi yezithako zokudla. Ngo-2023, imboni iyonke yezithako zokudla ikhule ngo-4.4%, kanti isigaba sokuguga okunempilo sifinyelele izinga lokukhula ngo-5.5%.I-NBJiphrojekthi yokuthi ukuthengiswa kwezithako zokudla ezinempilo zokuguga—okuqukethe izigaba ezahlukene zezifo ezithile—kuzodlula u-$1 billion ngo-2024 futhi kufinyelele u-$1.04 billion ngo-2026, okumele izinga lokukhula lika-7.7%.

Ukukhathazeka Kwabathengi Ngezinkinga Zempilo Ezihlobene Nobudala

I-AnI-NBJUcwaningo olwenziwa ngo-2024 luhlole ukukhathazeka kwabathengi okuhlobene nokuguga. Izinkinga ezibalulekile zifaka:

Ukulahlekelwa ukuhamba (28%)
Isifo se-Alzheimer noma i-dementia (23%)
Ukulahlekelwa umbono (23%)
Ukulahlekelwa ukuzimela (19%)
Izinselele zempilo yengqondo noma yengqondo (19%)
Ukuwohloka kwemisipha noma kwamathambo (19%)
Ukulahlekelwa izinwele (16%)
Ukungalali (16%)

Umthombo wesithombe: NBJ

Lapho kusetshenziswa izithasiselo, amasosha omzimba (35%) avele njengokukhathazeka okukhulu kwezempilo okuhlobene nobudala kubathengi. Ezinye izinto eziza kuqala zazihlanganisa impilo yamathumbu nokugaya ukudla (28%), impilo yokulala (23%), izinwele, isikhumba, nezinzipho (22%), impilo yemisipha namalunga (21%), impilo yenhliziyo (19%), kanye nenhlalakahle engokomzwelo (19%).

Umthombo wesithombe: NBJ

Izithako Ezinhlanu Ezibalulekile Zokulwa Nokuguga
1. I-Ergothioneine

I-Ergothioneine iyi-amino acid eyenzeka ngokwemvelo eyatholakala ngo-1909 nguCharles Tanret ngenkathi efunda nge-ergot fungi. I-thiol yayo eyingqayizivele kanye ne-thione tautomerism ku-pH yemvelo iyinika izakhiwo ezihlukile ze-antioxidant. Ngokusho kwedatha evela ku-Bloomage Biotech, i-ergothioneine ku-Bioyouth™-EGT ikhombisa umsebenzi wokususa ama-free radical e-DPPH izikhathi ezingu-14 kune-glutathione kanye nezikhathi ezingu-30 kune-coenzyme Q10.

Izinzuzo:

Isikhumba:I-Ergothioneine ivikela ekuvuvukeni okubangelwa yi-UV, ivimbela ukulimala kwe-DNA, futhi ikhuthaza ukwenziwa kwe-collagen ngenkathi inciphisa ukuwohloka kwe-collagen okuhlobene ne-UV.
Ubuchopho:I-Ergothioneine isekela ukusebenza kwengqondo, njengoba kufakazelwa ucwaningo lwezokwelapha olubonisa ukuthuthuka kokuqonda ngemva kwamasonto ayi-12 okwengeza i-ergothioneine etholakala kumakhowe.
Ukulala:Inqamula umgoqo wegazi nobuchopho, inciphisa ukwakheka kwe-peroxynitrite, futhi inciphise ukucindezeleka, ikhuthaza ukulala okungcono.

2. I-Spermidine

I-Spermidine, eyingxenye yomndeni we-polyamine, itholakala kabanzi ezintweni eziphilayo ezifana namabhaktheriya, isikhunta, izitshalo, nezilwane. Imithombo evamile yokudla ifaka phakathi i-wheat germ, ubhontshisi, kanye namakhowe e-king oyster. Amazinga e-Spermidine ayancipha ngokuguga, futhi imiphumela yayo yokulwa nokuguga ibangelwa izindlela ezifana nokufakwa kwe-autophagy, umsebenzi wokulwa nokuvuvukala, kanye nokulawulwa kwe-lipid metabolism.

Izindlela:

I-Autophagy:I-Spermidine ikhuthaza izinqubo zokuvuselela amaseli, ibhekana nezifo ezihlobene nokuguga ezihlobene nokukhubazeka kwe-autophagy.

Ukulwa nokuvuvukala: Kunciphisa ama-cytokine akhuthaza ukuvuvukala ngenkathi kwandisa izici zokulwa nokuvuvukala.

Ukuguqulwa Kwamafutha Egazini:I-Spermidine inethonya elihle ekuhlanganisweni nasekugcinweni kwamafutha, isekela ukugeleza kwe-membrane yamaseli kanye nokuphila isikhathi eside.

3. I-Pyrroloquinoline Quinone (PQQ)

I-PQQ, i-quinone coenzyme encibilika emanzini, ibalulekile ekusebenzeni kwe-mitochondrial. Ivikela ekulimaleni kwe-mitochondrial okubangelwa ukucindezeleka kwe-oxidative, ikhuthaza i-mitochondrial biogenesis, futhi ithuthukisa ukukhiqizwa kwe-nerve growth factor (NGF). Izifundo zemitholampilo zibonisa ukusebenza kwayo ekuthuthukiseni ukusebenza kwengqondo kanye nokugeleza kwegazi kwesifunda kubantu asebekhulile.

4. I-Phosphatidylserine (PS)

I-PS iyi-phospholipid ye-anionic ezingxenyeni zamaseli e-eukaryotic, ebalulekile ezinqubweni ezifana nokusebenza kwe-enzyme, i-apoptosis yamaseli, kanye nomsebenzi we-synaptic. Ithathwe emithonjeni efana ne-soya, izinto eziphilayo zasolwandle, kanye ne-sunflower, i-PS isekela izinhlelo ze-neurotransmitter, okuhlanganisa i-acetylcholine ne-dopamine, ezixhunyaniswe nempilo yengqondo.

Izicelo:Ukwengezwa kwe-PS kuhlotshaniswa nokuthuthuka kwezimo ezifana ne-Alzheimer's, isifo sikaParkinson, kanye nokucindezeleka, futhi kusiza abantu abane-ADHD kanye nezinkinga ze-autism spectrum.

5. I-Urolithin A (UA)

I-UA, i-metabolite yama-ellagitannins atholakala ekudleni okufana namapomegranate nama-walnuts, yatholakala ngo-2005. Ucwaningo lwanyatheliswa ku-Imithi Yemvelo(2016) ibonise ukuthi i-UA ikhuthaza i-mitophagy, yandisa isikhathi sokuphila sama-nematode ngo-45%. Ivuselela izindlela ze-mitochondrial autophagy, ihlanze i-mitochondria eyonakele futhi ibhekane nokungasebenzi kahle okuhlobene nobudala empilweni yemisipha, yenhliziyo, yomzimba, kanye neyesikhumba.

Indlela ye-mitophagy esebenzayo ye-UA/Ireferensi yomthombo wesithombe 1

Isiphetho

Njengoba abathengi beqhubeka nokubeka impilo nokuphila isikhathi eside phambili, isidingo sezithako ezintsha zokulwa nokuguga kanye nezithako zokudla siyaqhubeka nokukhula. Izithako ezibalulekile njenge-ergothioneine, i-spermidine, i-PQQ, i-PS, kanye ne-UA zivula indlela yezixazululo eziqondiwe ezinkingeni ezihlobene nokuguga. Lezi zinhlanganisela ezisekelwa ngokwesayensi zigcizelela ukuzibophezela kwemboni ekusekeleni ukuguga okunempilo nokunempilo.