Eminyakeni yamuva nje, inkinga yokukhuluphala emhlabeni wonke iye yaba nzima kakhulu. Ngokusho kwe-“Global Obesity Atlas 2025” ekhishwe yi-World Obesity Federation, inani eliphelele labantu abadala abakhuluphele emhlabeni wonke kulindeleke ukuthi likhuphuke lisuka ku-524 million ngo-2010 liye ku-1.13 billion ngo-2030, okuwukwenyuka okungaphezu kuka-115%. Ngokuphikisana nalokhu, inani elikhulayo labathengi lifuna izithako zemvelo ezingasiza ekuvimbeleni ukukhuluphala. NgoJuni kulo nyaka, ucwaningo olwanyatheliswa ephephabhukwini elithi “npj science of food” luveze ukuthi i-curcumin inciphise ukuqongelela kwamafutha e-visceral kumagundane e-MASH ngokuvimbela ukukhishwa kwama-polypeptides avimbela i-gastric inhibitory (GIP) abangelwa ukulimala kwamathumbu okungenawo umoya. Lokhu kutholakala akugcini nje ngokunikeza imibono emisha yokulwa nokukhuluphala kodwa futhi kwandisa imakethe yokusetshenziswa kwe-curcumin.
I-curcumin ikuvimbela kanjani ukuqongelela kwamafutha e-visceral? Ukuqongelela kwamafutha e-visceral kubhekisela ekuqongeleleni kwamafutha okungajwayelekile noma okweqile. Ukudla okunama-carbohydrate amaningi, okunamafutha amaningi kanye nokuntuleka kokuvivinya umzimba konke kungaholela ekungalingani kwamandla, ngaleyo ndlela kubangele amafutha e-visceral amaningi. Umgudu wokugaya ukudla uyindawo ebalulekile yokumuncwa kwamafutha. Ukuqongelela kwamafutha e-visceral kuyisici esibalulekile se-steatohepatitis (MASH) ehlobene nokungasebenzi kahle kwe-metabolic. Ngokusho kocwaningo, kokubili i-curcumin kanye nama-antibiotic kunganciphisa isisindo somzimba samagundane e-MASH, kanti i-curcumin kanye nama-antibiotic anomphumela wokubambisana.
Ucwaningo lwendlela yokusebenza luthole ukuthi i-curcumin inciphisa kakhulu isisindo samafutha e-visceral, ikakhulukazi ezicutshini ze-perirenal. I-Curcumin ivimbela ukukhuluphala ngokucindezela ukukhishwa kwe-GIP nokunciphisa inkomba yezicubu zamafutha ezizungeze izinso. Ukunciphisa ukukhululwa kwe-GIP emathunjini okubangelwa yi-curcumin kuvimbela ukusebenza kwama-receptor e-GIP, ngaleyo ndlela kunciphise i-adipogenesis nokuvuvukala kwezicubu ze-perirenal adipose. Ngaphezu kwalokho, i-curcumin inganciphisa i-hypoxia emathunjini amancane ngokuvikela i-epithelium yamathumbu kanye nomgoqo wemithambo yegazi, ngaleyo ndlela kuncishiswe ukukhishwa kwe-GIP. Ekuphetheni, umphumela we-pharmacological we-curcumin emathunjini e-visceral ikakhulukazi wenza buthaka ukukhishwa kwe-GIP ngokuvimbela i-hypoxia ebangelwa ukuphazamiseka komgoqo wamathumbu.
I-Curcumin, "uchwepheshe wokulwa nokuvuvukala", ivela kakhulu ezimpandeni nasema-rhizomes e-Curcuma (Curcuma longa L.). Iyinhlanganisela ye-polyphenolic enesisindo esincane futhi ivame ukusetshenziswa njengesinongo ekudleni okuhlukahlukene. Ngo-1815, uVegel nabanye babike okokuqala ngokuhlukaniswa "kwento ephuzi-orenji" kusuka ku-rhizome ye-turmeric futhi bayiqamba ngokuthi i-curcumin. Kwaze kwaba ngo-1910 lapho uKazimierz nabanye ososayensi banquma khona isakhiwo sayo samakhemikhali njenge-diferulic acylmethane. Ubufakazi obukhona bubonisa ukuthi i-curcumin inomphumela obalulekile wokulwa nokuvuvukala. Ingasebenzisa umphumela wayo wokulwa nokuvuvukala ngokuvimbela indlela ye-Toll-like receptor 4 (TLR4) kanye nendlela yayo yokubonisa ye-nuclear factor kB (NF-kB), kanye nokunciphisa ukukhiqizwa kwezinto ezibangela ukuvuvukala njenge-interleukin-1 β(IL-1β) kanye ne-tumor necrosis factor -α(TNF-α). Okwamanje, izakhiwo zayo zokulwa nokuvuvukala zibhekwa njengesisekelo semisebenzi eyahlukahlukene yezinto eziphilayo, futhi inani elikhulu lezifundo zangaphambi kokwelashwa noma zezokwelapha lihlole ukusebenza kwayo ezifweni zokuvuvukala. Phakathi kwazo, izifo zamathumbu ezivuvukalayo, i-arthritis, i-psoriasis, ukucindezeleka, i-atherosclerosis kanye ne-COVID-19 yizindawo zocwaningo ezishisayo zamanje.
Ngokuthuthuka kwemakethe yesimanje, kunzima ukufinyelela i-curcumin kumthamo ophumelelayo ngokudla kuphela futhi idinga ukuthathwa ngendlela yezithasiselo. Ngakho-ke, ikhule kakhulu emikhakheni yokudla okunempilo kanye nezithasiselo zokudla.
I-Justgood Health iphinde yakha izithasiselo ze-curcumin gummy ezahlukahlukene kanye nama-capsule e-curcumin. Abasabalalisi abaningi sebeze ukwenza ngokwezifiso umthamo noma ukuma okuhlukile komkhiqizo wabo.
Ucwaningo olwengeziwe ngezinzuzo ze-curcumin luthole ukuthi i-curcumin ayisizi nje kuphela ukumelana nokukhuluphala kodwa futhi inemiphumela eminingi efana nokulwa nokushiswa kwezicubu, ukuvikela imithambo yegazi, ukukhulula ubuhlungu bamathambo kanye nokusekela impilo yenhliziyo nemithambo yegazi. I-Antioxidant: Ucwaningo luthole ukuthi i-curcumin ingasusa ngqo ama-free radical futhi ithuthukise ukusebenza kwe-mitochondrial ngokusebenzisa izindlela ezifana nokuthulisa iphrotheni elawulayo 3 (SIRT3), ngaleyo ndlela inciphise ukukhiqizwa kwezinhlobo ze-oxygen ezisabela ngokweqile (ROS) ezivela emthonjeni futhi inciphise ngempumelelo umonakalo we-oxidative weseli. Ukuvikelwa kwemizwa: Ubufakazi bocwaningo obukhona bubonisa ukuthi ukuvuvukala kuhlobene kakhulu nokucindezeleka. I-Curcumin ingathuthukisa izimpawu zokucindezeleka nezokukhathazeka zeziguli ezinokucindezeleka. I-Curcumin ingasiza ekumelaneni nomonakalo we-neuronal obangelwa yi-interleukin-1 β (IL-1β) nezinye izici, futhi inciphise ukuziphatha okufana nokucindezeleka okubangelwa ukucindezeleka okungapheli. Ngakho-ke, ingadlala indima enhle ekusekeleni impilo yobuchopho kanye nokulawulwa ngokomzwelo. Ukuqeda ubuhlungu bemisipha: Izifundo zikhombisile ukuthi i-curcumin ingathuthukisa izimpawu zomtholampilo zezilwane eziyisibonelo se-arthritis futhi ivikele izicubu zamalunga nemisipha ngokunciphisa ukuvuvukala. I-Curcumin ingaqeda ubuhlungu bemisipha ngoba ingavimbela kakhulu ukukhishwa kwezinto ezibangela ukuvuvukala njenge-tumor necrosis factor -α(TNF-α) kanye ne-interleukin-1 β(IL-1β), inciphise izimpendulo zokuvuvukala kwendawo, ngaleyo ndlela inciphise izimpawu zokuvuvukala nobuhlungu bamalunga. Ukusekela impilo yenhliziyo nemithambo yegazi: Ngokuphathelene nesimiso senhliziyo nemithambo yegazi, i-curcumin ingasebenza ngokulawula amafutha egazini, inciphise i-cholesterol ephelele egazini, ama-triglycerides kanye namazinga e-cholesterol e-lipoprotein aphansi, kuyilapho ikhulisa amazinga e-cholesterol e-lipoprotein aphezulu. Ngaphezu kwalokho, i-curcumin ingavimbela nokwanda kwamaseli emisipha ebushelelezi yemithambo yegazi kanye nezimpendulo zokuvuvukala, okuwusizo ekuvimbeleni ukwenzeka nokuthuthukiswa kwezifo zenhliziyo ezifana ne-atherosclerosis.
Isikhathi sokuthunyelwe: Jan-08-2026