Muva nje, u-Akay Bioactives, umkhiqizi wase-US wezithako zokudla okunomsoco, ushicilele ucwaningo olungahleliwe, olulawulwa yi-placebo mayelana nemiphumela yesithako sayo se-Immufen™ ku-rhinitis engezwani ne-allergic emild, inkimbinkimbi ye-turmeric kanye notamatisi odakiwe waseNingizimu Afrika. Imiphumela yocwaningo ibonise ukuthi i-turmeric kanye ne-South African intoxicant extracts ingakwazi ukukhulula i-rhinitis ye-allergic.
I-Allergic Rhinitis, ekhathaza impilo yabantu abangaphezu kwezigidi ezingama-400
I-Allergic rhinitis (AR) yisifo esivamile sokuvuvukala kwepheshana lokuphefumula eliphezulu esithinta abantu abangaphezu kwezigidi ezingu-400 emhlabeni wonke, futhi ukwanda kwaso kunyukile eminyakeni embalwa edlule. Izici zayo zihlanganisa ukuthimula, ikhala eligijimayo, ukuminyana emakhaleni, nokuluma kwamehlo, ikhala nolwanga. Ivamise ukuhambisana nezinye izimo ezifana nesifuba somoya, i-conjunctivitis, ne-sinusitis, okungaholela ekwehleni kwezinga lempilo, ukungasebenzi kahle kwengqondo, ukusebenza kabi komsebenzi, kanye nekhwalithi yokulala ephansi.
Izindlela eziyinhloko ku-pathogenesis ye-rhinitis ye-allergic ukungalingani phakathi kohlobo lwe-T cell umsizi (Th1) kanye nohlobo lwe-T cell umsizi (Th2), nokungalingani phakathi kokuzivikela okungaphakathi nokuguquguqukayo okuhlanganisa amangqamuzana e-antigen-presenting, i-lymphocyte nama-T cell.
Ukwelashwa kwe-rhinitis engezwani nomzimba kuvame ukwenziwa ngama-antihistamine noma ama-decongestants amakhala, futhi nakuba ama-antihistamine ethuthukisiwe ezizukulwaneni ezimbalwa, angase abangele uhla lwemiphumela emibi efana nekhanda elibuhlungu, ukukhathala, ukozela, i-pharyngitis, nesiyezi. Imithi yokwelapha ngamakhambi manje isivela njengomuthi ohambisanayo ophephile noma ohlukile wokuthuthukisa kanye/noma ukuphatha izimo ze-AR.
I-Turmeric + Utamatisi WaseNingizimu Afrika Odakiwe Ithuthukisa Ngokuphawulekayo I-AR
Ocwaningweni olushicilelwe ngabakwa-Akay Bioactives, ababambiqhaza abangu-105 babelwa ngokungahleliwe ukuthi bathole i-turmeric extract ne-South African drunken tomato extract (CQAB, i-capsule ngayinye ye-CQAB ihlanganisa i-95 ± 5 mg curcumin kanye ne-125 mg yaseNingizimu Afrika ekhishwe utamatisi odakiwe), i-curcumin etholakalayo (CGM), i-capsule ngayinye ye-CGM iqukethe i-250 mg curcumin), noma i-placebo kabili ngosuku izinsuku ezingu-28. Ngokuhlaziywa kwe-covariance (ANCOVA), i-CQAB itholakale inciphisa kakhulu izimpawu ezihlobene ne-rhinitis ehlobene ne-allergen uma kuqhathaniswa ne-CGM ne-placebo. Uma kuqhathaniswa ne-placebo: ukuminyana emakhaleni kwehliswe ngo-34.64%, ikhala eligijima ngo-33.01%, ikhala elilumayo ngo-29.77%, ukuthimula ngo-32.76%, kanye neTotal Symptom Symptom Score (TNSS) ngama-31.62%; uma kuqhathaniswa ne-CGM: ukuminyana emakhaleni kwehle ngo-31.88%, ikhala eligijima ngo-53.13%, ikhala elilumayo ngo-24.98%, ukuthimula ngo-2.93%, kanye nokwehla ngo-25.27% ku-Total Nasal Symptom Score (TNSS).
I-Ayurvedic monograph i-Dhanwantari Nighantu ikhuluma nge-turmeric njengesivikelo nokwelashwa kwe-rhinitis. Isitshalo seqanda esidakiwe sisetshenziselwa ukwelapha ukuminyana emakhaleni (ukumisa ukukhwehlela kanye nobunzima bokuphefumula) kanye nokwenza ngcono amandla. Inhlanganisela yalawa makhambi amabili ingaba nomphumela we-synergistic we-pharmacological futhi ngaleyo ndlela ithuthukise i-rhinitis yokungezwani komzimba.I-Akay Bioactives eshicilelwe ucwaningo oluthola ukuthi ikhono le-curcumin lokushintsha isimiso somzimba sokuzivikela ezifweni lincike ekusebenzelaneni kwayo nezinhlobonhlobo zamamodulators omzimba, njengamaseli B, T. amangqamuzana, amangqamuzana e-dendritic, amangqamuzana abulalayo emvelo, ama-neutrophil, nama-macrophage; kanye nokuthi izithako ezisebenzayo zikatamatisi wokudakwa waseNingizimu Afrika (udakwa utamatisi lactone kanye nezakhi ezisebenzayo ze-hepatica yaseNingizimu Afrika (i-hepatica lactone kanye ne-hepatica lactone glycosides) zingasebenzisa imiphumela yazo yokuzivikela komzimba ngokuhlanganisa nokuvula ama-macrophage.
Abantu abahlushwa izimpawu ze-rhinitis engezwani nomzimba bavame ukuba nekhwalithi yokulala engeyinhle, okungase kuholele ekwehleni kwekhono lokufunda, ukufunda okuphansi/ukukhiqiza, kanjalo nezinga lempilo eliphansi. Nakuba i-curcumin ku-turmeric inganciphisa ukubambezeleka kokulala futhi ikhulise ubude bokulala kumagundane; ukudakwa i-lactone ekudakweni kwaseNingizimu Afrika kungadambisa ingcindezi futhi kuthuthukise ukulala. Ngakho-ke, kungase kucatshangwe ukuthi imiphumela ye-synergistic yezidakamizwa zaseNingizimu Afrika kanye ne-curcumin ingase inikeze imiphumela ekhuthaza ukulala ye-CQAB.
Ukwengeza, ababambiqhaza ocwaningweni olushicilelwe babike amazinga anda okuphazamiseka kwemizwelo, ukukhathala, nokuncipha kwamandla ekuqaleni kocwaningo. Futhi i-curcumin ithuthukise kakhulu isimo sengqondo esibi. Ngokufanayo, i-South African Drunken Tomato Extract yaziwa ngokunciphisa ingcindezi futhi ikhulise amandla, ngaleyo ndlela ithuthukise izinga lempilo kanye nekhono lokusebenza emsebenzini. Phakathi kwezinye izinto, Utamatisi Odakiwe waseNingizimu Afrika ungase wehlise ukusebenza kwe-hypothalamic-pituitary-adrenal axis (HPA). Ekuphenduleni izisusa ezicindezelayo, i-axis ye-HPA ngokungaqondile inomthelela ekugxilweni okuphezulu kwe-cortisol ne-dehydroepiandrosterone (DHEA), futhi amazinga aphansi e-DHEA ayimbangela yezinkinga eziningi ezingokwengqondo, ezingokwengqondo nezingokwengqondo.
Izicelo Zomkhiqizo we-Turmeric + Utamatisi Odakiwe waseNingizimu Afrika
Idatha ye-Futuremarketinsights yembula ukuthi usayizi wemakethe ye-turmeric yomhlaba wonke ungafinyelela ku-USD 4,419.3 million ngo-2023. Ikhula ku-CAGR ka-5.5% ngesikhathi sokubikezela (2023-2033), imakethe iyonke izoba yigugu ngaphezu kwezigidi ezingu-USD 7,579.2 ngo-2033.
Ngaleso sikhathi, usayizi wemakethe ekhipha izinto ezidakayo yaseNingizimu Afrika emhlabeni wonke ungafinyelela ku-USD 698.0 million ngo-2023 futhi kulindeleke ukuthi ufinyelele ezigidini ezilinganiselwa ku-USD 1,523.0 ngo-2033. Ikhula ku-CAGR ka-8.1% ngesikhathi sokubikezela (2023-2033). Umphumela we-synergistic we-turmeric nezidakamizwa zaseNingizimu Afrika kufakazelwe ukuthi unezinzuzo ezibalulekile zezempilo futhi usetshenziswa emikhiqizweni ehlukahlukene.
Impilo Enhle njekungenziwa ngezifiso ngobuningi
(1) Isengezo esiqukethe i-turmeric kanye ne-hepatica yaseNingizimu Afrika, engangezwa emanzini ashisayo noma obisini futhi idliwe ndawonye. Iqinisa amasosha omzimba, amandla nokubekezela, ilwa nemikhuhlane nomkhuhlane, ithuthukise ukugaya kanye nokubona.
(2) Isithasiselo esiqukethe i-curcumin notamatisi onekhanda laseNingizimu Afrika, umkhiqizo ungagcina abantu begcwele amandla, usize ekusimamiseni isimo sengqondo, futhi uqinisekise impilo yamalunga nezinye izitho zomzimba.
(3) Ingxube yezitshalo equkethe i-hepatica yaseNingizimu Afrika ne-curcumin, ekhulula ukudangala okubangelwa ukucindezeleka futhi igcine isimo sengqondo esijabulisayo.
(4) Iziphuzo eziqukethe i-turmeric kanye nogwayi odakayo waseNingizimu Afrika, ongenawo ushukela owengeziwe, zisiza abantu ukuba bathuthukise ukucabanga kwabo futhi balondoloze ukugxilisa ingqondo.
Isikhathi sokuthumela: Nov-21-2024