I-Astaxanthin (3,3'-dihydroxy-beta, beta-carotene-4,4'-dione) iyi-carotenoid, ehlukaniswe njenge-lutein, etholakala ezinhlotsheni eziningi zezinambuzane nezilwane zasolwandle, futhi ekuqaleni yahlukaniswa nama-lobster nguKuhn noSorensen. Ingumbala oncibilikayo emafutheni obonakala ngombala ophuzi kuya kobomvu futhi awunawo umsebenzi we-vitamin A emzimbeni womuntu.
Imithombo yemvelo ye-astaxanthin ifaka phakathi ulwelwe, imvubelo, i-salmon, i-trout, i-krill kanye ne-crayfish. I-astaxanthin yezentengiselwano itholakala kakhulu ku-Fife yeast, ulwelwe obomvu kanye nokuhlanganiswa kwamakhemikhali. Omunye wemithombo engcono kakhulu ye-astaxanthin yemvelo yi-chlorella ebomvu ethosiwe imvula, enokuqukethwe kwe-astaxanthin okungaba ngu-3.8% (ngesisindo esomile), kanti i-salmon yasendle nayo iyimithombo emihle ye-astaxanthin. Ukukhiqizwa kokwenziwa kusengumthombo oyinhloko we-astaxanthin ngenxa yezindleko eziphezulu zokutshala i-Rhodococcus rainieri ngezinga elikhulu. Umsebenzi webhayoloji we-astaxanthin ekhiqizwa ngokwenziwa ungama-50% kuphela we-astaxanthin yemvelo.
I-Astaxanthin ikhona njenge-stereoisomers, ama-isomers e-geometric, amafomu akhululekile naqinisiwe, kanti ama-stereoisomers (3S,3'S) kanye ne-(3R,3'R) yiwona atholakala kakhulu emvelweni. I-Rhodococcus rainieri ikhiqiza i-(3S,3'S)-isomer kanti i-Fife yeast ikhiqiza i-(3R,3'R)-isomer.
I-Astaxanthin, ukushisa kwamanje
I-Astaxanthin iyisithako esiyinhloko ekudleni okusebenzayo eJapan. Izibalo ze-FTA mayelana nezimemezelo zokudla okusebenzayo eJapan ngo-2022 zithole ukuthi i-astaxanthin yayibekwe endaweni yesi-7 phakathi kwezithako eziyi-10 eziphezulu ngokwemvamisa yokusetshenziswa, futhi yayisetshenziswa kakhulu emikhakheni yezempilo yokunakekelwa kwesikhumba, ukunakekelwa kwamehlo, ukukhululeka ekukhathaleni, kanye nokuthuthukiswa komsebenzi wokuqonda.
Emiklomelweni Yezithako Zokudla Zase-Asia ka-2022 no-2023,Impilo kaJustgood Isithako se-astaxanthin yemvelo saqashelwa njengesithako esihle kakhulu sonyaka iminyaka emibili ilandelana, isithako esihle kakhulu kuthrekhi yomsebenzi wokuqonda ngo-2022, kanye nesithako esihle kakhulu kuthrekhi yobuhle bomlomo ngo-2023. Ngaphezu kwalokho, lesi sithako safakwa ohlwini olufushane ku-Asian Nutritional Ingredients Awards - Healthy Aging track ngo-2024.
Eminyakeni yamuva nje, ucwaningo lwezemfundo nge-astaxanthin nalo seluqalile ukufudumala. Ngokusho kwedatha ye-PubMed, kusukela ngo-1948, kube nezifundo nge-astaxanthin, kodwa ukunaka bekuphansi, kusukela ngo-2011, izazi zemfundo zaqala ukugxila ku-astaxanthin, ngezincwadi ezingaphezu kwe-100 ngonyaka, kanye nezingaphezu kuka-200 ngo-2017, ezingaphezu kuka-300 ngo-2020, kanye nezingaphezu kuka-400 ngo-2021.
Umthombo wesithombe: I-PubMed
Ngokuphathelene nemakethe, ngokusho kwe-Future market insights, usayizi wemakethe ye-astaxanthin yomhlaba wonke ulinganiselwa ku-USD 273.2 million ngo-2024 futhi kulindeleke ukuthi ufinyelele ku-USD 665.0 million ngo-2034, ku-CAGR engu-9.3% ngesikhathi sokubikezela (2024-2034).
Amandla aphezulu okulwa ne-antioxidant
Isakhiwo esiyingqayizivele se-Astaxanthin siyinika amandla amahle kakhulu okulwa ne-antioxidant. I-Astaxanthin iqukethe ama-double bond ahlanganisiwe, amaqembu e-hydroxyl kanye ne-ketone, futhi i-lipophilic futhi i-hydrophilic. I-double bond ehlanganisiwe enkabeni yenhlanganisela inikeza ama-electron futhi isabela nama-free radicals ukuze iwaguqule abe imikhiqizo ezinzile futhi iqede ukusabela kwama-free radical chain ezintweni eziphilayo ezahlukahlukene. Umsebenzi wayo webhayoloji uphakeme kunowamanye ama-antioxidants ngenxa yekhono layo lokuxhuma kuma-membrane eseli kusuka ngaphakathi kuya ngaphandle.
Indawo ye-astaxanthin namanye ama-antioxidants emangqamuzaneni eseli
I-Astaxanthin inomsebenzi obalulekile we-antioxidant hhayi nje ngokukhipha ama-free radicals ngqo, kodwa futhi nangokusebenzisa uhlelo lokuvikela ama-antioxidant lwamaseli ngokulawula indlela ye-nuclear factor erythroid 2-related factor (Nrf2). I-Astaxanthin ivimbela ukwakheka kwe-ROS futhi ilawula ukuvezwa kwama-enzyme aphendula ukucindezeleka kwe-oxidative, njenge-heme oxygenase-1 (HO-1), okuwuphawu lokucindezeleka kwe-oxidative. I-HO-1 ilawulwa yizinhlobo ezahlukene zezinto zokubhala ezithinta ukucindezeleka, kufaka phakathi i-Nrf2, ebopha ezintweni eziphendula ukucindezeleka kwe-antioxidant esifundeni sokukhuthaza ama-enzyme e-metabolism e-detoxification.
Uhla oluphelele lwezinzuzo ze-astaxanthin kanye nezicelo
1) Ukuthuthukiswa komsebenzi wokuqonda
Izifundo eziningi ziqinisekisile ukuthi i-astaxanthin ingase ilibazise noma ithuthukise ukuntuleka kokuqonda okuhambisana nokuguga okuvamile noma inciphise i-pathophysiology yezifo ezahlukahlukene ze-neurodegenerative. I-Astaxanthin inganqamula isithiyo segazi-ubuchopho, futhi izifundo zibonise ukuthi i-astaxanthin yokudla iqoqana ku-hippocampus kanye ne-cerebral cortex yobuchopho begundane ngemva kokudla kanye nokuphindaphindiwe, okungase kuthinte ukugcinwa kanye nokuthuthukiswa komsebenzi wokuqonda. I-Astaxanthin ikhuthaza ukuvuselelwa kwamaseli ezinzwa futhi ikhulisa ukubonakaliswa kwezakhi zofuzo ze-glial fibrillary acidic protein (GFAP), i-microtubule-associated protein 2 (MAP-2), i-brain-derived neurotrophic factor (BDNF), kanye ne-growth-associated protein 43 (GAP-43), amaprotheni ahilelekile ekubuyiselweni kobuchopho.
Ama-Capsule e-Justgood Health Astaxanthin, ane-Cytisine kanye ne-Astaxanthin avela e-Red Algae Rainforest, ayasebenzisana ukuthuthukisa ukusebenza kobuchopho ngokwengqondo.
2) Ukuvikelwa Kwamehlo
I-Astaxanthin inomsebenzi we-antioxidant oqeda amandla ama-molecule angenawo umoya-mpilo futhi ivikele amehlo. I-Astaxanthin isebenza ngokubambisana namanye ama-carotenoid asekela impilo yamehlo, ikakhulukazi i-lutein ne-zeaxanthin. Ngaphezu kwalokho, i-astaxanthin yandisa izinga lokugeleza kwegazi esweni, okuvumela igazi ukuthi livuselele umoya-mpilo ku-retina kanye nezicubu zamehlo. Izifundo zikhombisile ukuthi i-astaxanthin, ngokuhlanganiswa namanye ama-carotenoid, ivikela amehlo ekulimaleni kuwo wonke ama-solar spectrum. Ngaphezu kwalokho, i-astaxanthin isiza ekunciphiseni ukungakhululeki kwamehlo kanye nokukhathala kokubona.
Ama-Softgels e-Justgood Health Blue Light Protection, Izithako ezibalulekile: i-lutein, i-zeaxanthin, i-astaxanthin.
3) Ukunakekelwa Kwesikhumba
Ukucindezeleka kwe-oxidative kuyimbangela ebalulekile yokuguga kwesikhumba somuntu kanye nomonakalo wesikhumba. Indlela yokuguga kwangaphakathi (kwesikhathi) kanye nokwangaphandle (okukhanya) ukukhiqizwa kwe-ROS, ngokwemvelo ngokusebenzisa i-oxidative metabolism, kanye nangaphandle ngokuchayeka emisebeni yelanga ye-ultraviolet (UV). Izehlakalo ze-oxidative ekugugeni kwesikhumba zifaka phakathi ukulimala kwe-DNA, izimpendulo zokuvuvukala, ukuncipha kwama-antioxidants, kanye nokukhiqizwa kwama-matrix metalloproteinases (MMPs) abhubhisa i-collagen ne-elastin ku-dermis.
I-Astaxanthin ingavimbela ngempumelelo umonakalo we-oxidative obangelwa yi-free radical kanye nokufakwa kwe-MMP-1 esikhumbeni ngemva kokuchayeka ku-UV. Izifundo zibonise ukuthi i-astaxanthin evela ku-Erythrocystis rainbowensis ingandisa okuqukethwe kwe-collagen ngokuvimbela ukuvezwa kwe-MMP-1 kanye ne-MMP-3 kuma-fibroblast esikhumba somuntu. Ngaphezu kwalokho, i-astaxanthin yanciphisa umonakalo we-DNA obangelwa yi-UV kanye nokwanda kokulungiswa kwe-DNA kumaseli abhekene nemisebe ye-UV.
I-Justgood Health okwamanje yenza izifundo eziningana, okuhlanganisa amagundane angenazinwele kanye nezivivinyo zabantu, zonke ezibonise ukuthi i-astaxanthin inciphisa umonakalo we-UV ezingqimbeni ezijulile zesikhumba, okubangela ukubonakala kwezimpawu zokuguga kwesikhumba, njengokoma, isikhumba esiwohlokayo kanye nemibimbi.
4) Ukudla okunempilo kwezemidlalo
I-Astaxanthin ingasheshisa ukulungiswa ngemva kokuzilolonga. Lapho abantu bezilolonga noma bezilolonga, umzimba ukhiqiza inani elikhulu le-ROS, okuthi uma lingasuswa ngesikhathi, lingalimaza imisipha futhi lithinte ukululama komzimba, kuyilapho umsebenzi we-astaxanthin onamandla wokulwa ne-antioxidant ungasusa i-ROS ngesikhathi futhi ulungise imisipha eyonakele ngokushesha.
I-Justgood Health yethula i-Astaxanthin Complex yayo entsha, inhlanganisela ehlukahlukene ye-magnesium glycerophosphate, i-vitamin B6 (pyridoxine), kanye ne-astaxanthin enciphisa ubuhlungu bemisipha kanye nokukhathala ngemva kokuzivocavoca. Le fomula igxile ku-Whole Algae Complex ye-Justgood Health, enikeza i-astaxanthin yemvelo engagcini nje ngokuvikela imisipha ekulimaleni kwe-oxidative, kodwa futhi ethuthukisa ukusebenza kwemisipha futhi ithuthukise ukusebenza kwezemidlalo.
5) Impilo Yenhliziyo Nemithambo Yegazi
Ukucindezeleka kwe-oxidative kanye nokuvuvukala kuveza i-pathophysiology yesifo senhliziyo nemithambo yegazi esine-atherosclerotic. Umsebenzi omuhle kakhulu we-astaxanthin wokulwa ne-antioxidant ungavimbela futhi uthuthukise i-atherosclerosis.
Ama-Softgel e-Justgood Health Triple Strength Natural Astaxanthin asiza ukugcina impilo yenhliziyo nemithambo yegazi ngokusebenzisa i-astaxanthin yemvelo etholakala ku-rainbow red algae, izithako zayo eziyinhloko zihlanganisa i-astaxanthin, uwoyela kakhukhunathi we-organic virgin kanye nama-tocopherols emvelo.
6) Ukulawulwa Kwamasosha Omzimba
Amaseli esistimu yokuzivikela omzimba azwela kakhulu ekulimaleni kwama-free radical. I-Astaxanthin ivikela ukuzivikela kwesistimu yokuzivikela ngokuvimbela umonakalo wama-free radical. Ucwaningo luthole ukuthi i-astaxanthin emaseli omuntu ukukhiqiza ama-immunoglobulins, emzimbeni womuntu i-astaxanthin supplementation amasonto ayi-8, amazinga e-astaxanthin egazini ayanda, amaseli e-T namaseli e-B ayanda, umonakalo we-DNA uyancipha, iphrotheni e-C-reactive incishiswe kakhulu.
Ama-softgel e-Astaxanthin, i-astaxanthin eluhlaza, asebenzisa ukukhanya kwelanga kwemvelo, amanzi ahlungiwe yi-lava kanye namandla elanga ukukhiqiza i-astaxanthin emsulwa nenempilo, engasiza ekuthuthukiseni amasosha omzimba, ukuvikela umbono kanye nempilo yamalunga.
7) Nciphisa Ukukhathala
Ucwaningo lwe-crossover oluthathe amasonto amane olungahleliwe, olungaboni kabili, olulawulwa yi-placebo, oluqhutshwa ngezindlela ezimbili luthole ukuthi i-astaxanthin ikhuthaza ukululama ekukhathaleni kwengqondo okubangelwa yi-visual display terminal (VDT), okunciphisa amazinga aphezulu e-plasma phosphatidylcholine hydroperoxide (PCOOH) ngesikhathi somsebenzi wengqondo nowomzimba. Isizathu kungaba umsebenzi we-antioxidant kanye nendlela yokulwa nokuvuvukala ye-astaxanthin.
8) Ukuvikelwa kwesibindi
I-Astaxanthin inemiphumela yokuvimbela nokunciphisa izinkinga zempilo ezifana ne-fibrosis yesibindi, ukulimala kwe-ischemia-reperfusion yesibindi, kanye ne-NAFLD. I-Astaxanthin ingalawula izindlela ezahlukahlukene zokubonisa izimpawu, njengokunciphisa umsebenzi we-JNK kanye ne-ERK-1 ukuthuthukisa ukumelana ne-insulin yesibindi, ukuvimbela ukubonakaliswa kwe-PPAR-γ ukunciphisa ukwakheka kwamafutha esibindini, kanye nokunciphisa ukubonakaliswa kwe-TGF-β1/Smad3 ukuvimbela ukusebenza kwe-HSCs kanye ne-fibrosis yesibindi.
Isimo semithethonqubo ezweni ngalinye
EShayina,i-astaxanthin kusuka emthonjeni we-rainbow red algae ingasetshenziswa njengesithako esisha sokudla ekudleni okuvamile (ngaphandle kokudla kwezingane), ngaphezu kwalokho, i-United States, iCanada kanye neJapan nazo zivumela i-astaxanthin ukuthi isetshenziswe ekudleni.
Isikhathi sokuthunyelwe: Disemba-05-2024