I-Astaxanthin (3,3'-dihydroxy-beta,beta-carotene-4,4'-dione) iyi-carotenoid, ehlukaniswa njenge-lutein, etholakala ezinhlobonhlobo zezilwanyana ezincane nezilwane zasolwandle, futhi ekuqaleni yayihlukanisiwe kuma-lobster nguKuhn kanye I-Sorensen. Kuyi-pigment encibilika ngamafutha ebonakala isawolintshi kuya kobomvu ngokujulile ngombala futhi ayinawo umsebenzi obalulekile kavithamini A emzimbeni womuntu.
Imithombo yemvelo ye-astaxanthin ihlanganisa ulwelwe, imvubelo, i-salmon, i-trout, i-krill ne-crayfish. I-astaxanthin yezohwebo ikakhulukazi isuselwa kumbiliso ye-Fife, i-algae ebomvu kanye nokuhlanganiswa kwamakhemikhali. Omunye wemithombo engcono kakhulu ye-astaxanthin yemvelo i-chlorella ebomvu edla imvula, enokuqukethwe kwe-astaxanthin okungaba ngu-3.8% (ngesisindo esomile), kanye nesalmon yasendle nayo iyimithombo emihle ye-astaxanthin. Ukukhiqizwa kwe-synthetic kusewumthombo oyinhloko we-astaxanthin ngenxa yezindleko eziphezulu zokutshala i-Rhodococcus rainieri. Umsebenzi webhayoloji we-astaxanthin okhiqizwa ngokwenziwa ungama-50% kuphela walowo we-astaxanthin yemvelo.
I-Astaxanthin ikhona njengama-stereoisomers, ama-isomers ejiyomethri, amafomu amahhala futhi aqinile, ane-stereoisomers (3S,3'S) kanye no-(3R,3'R) ayinsada kakhulu ngokwemvelo. I-Rhodococcus rainieri ikhiqiza i-(3S,3'S) -isomer kanye ne-Fife yeast ikhiqiza i-(3R,3'R) -isomer.
I-Astaxanthin, ukushisa kwesikhashana
I-Astaxanthin iyisithako senkanyezi ekudleni okusebenzayo e-Japan.Izibalo ze-FTA mayelana nokumenyezelwa kokudla okusebenzayo e-Japan ngo-2022 zathola ukuthi i-astaxanthin yabekwa endaweni engu-7 phakathi kwezithako ezingu-10 eziphezulu mayelana nemvamisa yokusetshenziswa, futhi yayisetshenziswa ikakhulukazi emikhakheni yezempilo ye-astaxanthin. ukunakekelwa kwesikhumba, ukunakekelwa kwamehlo, ukukhululeka kokukhathala, nokuthuthukiswa kokusebenza kwengqondo.
Emiklomelweni Yezithako Zokudla zase-Asia yango-2022 nango-2023, isithako se-astaxanthin esingokwemvelo se-Justgood Health sabonwa njengesithako esingcono kakhulu sonyaka iminyaka emibili ilandelana, isithako esingcono kakhulu ethrekhi yokusebenza kwengqondo ngo-2022, kanye nesithako esingcono kakhulu sengoma yobuhle bomlomo 2023. Ngaphezu kwalokho, isithako safakwa ohlwini olufushane ku Imiklomelo Yezithako Zokudla zase-Asia - Ithrekhi yokuguga enempilo ngo-2024.
Eminyakeni yamuva nje, ucwaningo lwezemfundo nge-astaxanthin nalo seluqale ukushisa. Ngokusho kwedatha ye-PubMed, kusukela ngo-1948, kwakukhona izifundo nge-astaxanthin, kodwa ukunakwa bekuphansi, kusukela ngo-2011, izifundiswa zaqala ukugxila ku-astaxanthin, ngokushicilelwa okungaphezu kwe-100 ngonyaka, nangaphezulu kuka-200 ngo-2017, ngaphezulu. kunama-300 ngo-2020, nangaphezulu kwama-400 ngo-2021.
Umthombo wesithombe:PubMed
Ngokwemakethe, ngokwemibono yemakethe yesikhathi esizayo, usayizi wemakethe ye-astaxanthin yomhlaba wonke ulinganiselwa ku-USD 273.2 million ngo-2024 futhi kulindeleke ukuthi ufinyelele ku-USD 665.0 million ngo-2034, ku-CAGR ka-9.3% ngesikhathi sokubikezela (2024-2034) ).
Umthamo omkhulu we-antioxidant
Isakhiwo esiyingqayizivele se-Astaxanthin siyinikeza amandla aphezulu kakhulu e-antioxidant. I-Astaxanthin iqukethe ama-conjugated double bond, amaqembu e-hydroxyl kanye ne-ketone, futhi i-lipophilic ne-hydrophilic. I-conjugated double bond enkabeni yenhlanganisela ihlinzeka ngama-electron futhi isabela ngama-radicals mahhala ukuze iwaguqule abe yimikhiqizo ezinzile futhi inqamule ukusabela kwamaketango amahhala ezinto eziphilayo ezihlukahlukene. Umsebenzi wayo webhayoloji uphakeme kunowamanye ama-antioxidants ngenxa yekhono lawo lokuxhuma kulwelwesi lwamaseli kusuka ngaphakathi nangaphandle.
Indawo ye-astaxanthin namanye ama-antioxidants kulwelwesi lwamaseli
I-Astaxanthin yenza umsebenzi obalulekile we-antioxidant hhayi kuphela ngokukhipha ngokuqondile ama-radicals mahhala, kodwa futhi ngokusebenzisa uhlelo lokuzivikela lwe-antioxidant lwamaselula ngokulawula indlela ye-nuclear factor erythroid 2-related factor (Nrf2). I-Astaxanthin ivimbela ukwakheka kwe-ROS futhi ilawula ukuvezwa kwama-enzyme asabela ekucindezelekeni kwe-oxidative, njenge-heme oxygenase-1 (HO-1), okuwuphawu lokucindezeleka okwenziwe nge-oxidative.HO-1 ilawulwa ukuloba okuhlukahlukene okuzwela ukucindezeleka izici, kuhlanganise ne-Nrf2, ebophezela ezintweni eziphendula i-antioxidant endaweni yomgqugquzeli we-detoxification metabolism enzymes.
Uhlu oluphelele lwezinzuzo ze-astaxanthin nezinhlelo zokusebenza
1) Ukuthuthukiswa kokusebenza kwengqondo
Ucwaningo oluningi luye lwaqinisekisa ukuthi i-astaxanthin ingase ibambezele noma ithuthukise ukushoda kwengqondo okuhlobene nokuguga okuvamile noma inciphise i-pathophysiology yezifo ezihlukahlukene ze-neurodeergenerative. I-Astaxanthin ingawela umgoqo wegazi nobuchopho, futhi ucwaningo luye lwabonisa ukuthi i-astaxanthin yokudla inqwabelana ku-hippocampus kanye ne-cerebral cortex yobuchopho begundane ngemva kokudla okukodwa nokuphindaphindiwe, okungase kuthinte ukugcinwa nokuthuthukiswa kokusebenza kwengqondo. I-Astaxanthin ikhuthaza ukuvuselelwa kwamangqamuzana ezinzwa futhi yandise ukubonakaliswa kofuzo kweprotheyini ye-glial fibrillary acidic (GFAP), iphrotheni ehambisana ne-microtubule 2 (MAP-2), i-neurotrophic factor (BDNF) etholakala ebuchosheni (BDNF), kanye nephrotheni ehlobene nokukhula 43 (GAP-43), amaprotheni athintekayo ekululameni kobuchopho.
I-Justgood Health Astaxanthin Capsules, ene-Cytisine ne-Astaxanthin evela e-Red Algae Rainforest, ayasebenzisana ukuze athuthukise ukusebenza kwengqondo.
2) Ukuvikelwa Kwamehlo
I-Astaxanthin inomsebenzi we-antioxidant owenza i-oxygen-free radical molecules ingasebenzi futhi inikeze ukuvikeleka kwamehlo. I-Astaxanthin isebenza ngokubambisana namanye ama-carotenoid asekela impilo yamehlo, ikakhulukazi i-lutein ne-zeaxanthin. Ngaphezu kwalokho, i-astaxanthin inyusa izinga lokugeleza kwegazi esweni, ivumela igazi ukuthi liphinde likhiphe i-retina nezicubu zamehlo. Ucwaningo selukhombisile ukuthi i-astaxanthin, ihlanganiswe namanye ama-carotenoid, ivikela amehlo ekulimaleni kuwo wonke umkhakha welanga. Ngaphezu kwalokho, i-astaxanthin isiza ekudambiseni ukungakhululeki kwamehlo nokukhathala okubukwayo.
I-Justgood Health Blue Light Protection Softgels, izithako ezibalulekile: i-lutein, i-zeaxanthin, i-astaxanthin.
3) Ukunakekelwa Kwesikhumba
Ukucindezeleka kwe-oxidative kuyimbangela ebalulekile yokuguga kwesikhumba somuntu kanye nokulimala kwesikhumba. Indlela yakho kokubili ukuguga kwangaphakathi (okulandelanayo) kanye nokuphuma ngaphandle (okukhanyayo) ukukhiqizwa kwe-ROS, ngaphakathi ngokusebenzisa i-oxidative metabolism, nangaphandle ngokuchayeka emisebeni yelanga ye-ultraviolet (UV). Izehlakalo ze-oxidative ekugugeni kwesikhumba zihlanganisa ukulimala kwe-DNA, ukusabela kokuvuvukala, ukuncishiswa kwama-antioxidants, nokukhiqizwa kwe-matrix metalloproteinases (MMPs) ehlisa i-collagen ne-elastin ku-dermis.
I-Astaxanthin inganqanda ngempumelelo umonakalo owenziwe nge-radical-induced oxidative kanye nokungeniswa kwe-MMP-1 esikhumbeni ngemva kokuchayeka kwe-UV. Ucwaningo luye lwabonisa ukuthi i-astaxanthin evela ku-Erythrocystis rainbowensis ingakhuphula okuqukethwe kwe-collagen ngokuvimbela ukuvezwa kwe-MMP-1 ne-MMP-3 ku-human dermal fibroblasts. Ngaphezu kwalokho, i-astaxanthin yehlisa ukulimala kwe-DNA eyenziwe yi-UV futhi yandisa ukulungiswa kwe-DNA kumaseli achayeke emisebeni ye-UV.
I-Justgood Health okwamanje yenza izifundo ezimbalwa, okuhlanganisa amagundane angenabo uboya kanye nokuhlolwa kwabantu, konke okuye kwabonisa ukuthi i-astaxanthin inciphisa ukulimala kwe-UV ezingqimbeni ezijulile zesikhumba, ezibangela ukubonakala kwezimpawu zokuguga kwesikhumba, njengokoma, ukuwohloka kwesikhumba kanye nesikhumba. imibimbi.
4) Umsoco wezemidlalo
I-Astaxanthin ingasheshisa ukulungiswa kwangemva kokuzivocavoca. Lapho abantu besebenzisa umzimba noma bavivinya umzimba, umzimba ukhiqiza inani elikhulu le-ROS, okuthi, uma lingasuswanga ngesikhathi, lingalimaza imisipha futhi lithinte ukululama ngokomzimba, kuyilapho umsebenzi oqinile we-antioxidant we-astaxanthin ungasusa i-ROS ngesikhathi futhi ulungise imisipha eyonakele ngokushesha.
I-Justgood Health yethula i-Astaxanthin Complex yayo entsha, inhlanganisela eminingi ye-magnesium glycerophosphate, uvithamini B6 (pyridoxine), kanye ne-astaxanthin enciphisa ubuhlungu bemisipha nokukhathala ngemva kokuzivocavoca. Ifomula igxile ku-Justgood Health's Whole Algae Complex, eletha i-astaxanthin yemvelo engavikeli nje izicubu emonakalweni we-oxidative, kodwa futhi ithuthukisa ukusebenza kwemisipha futhi ithuthukise ukusebenza kwezemidlalo.
5) Impilo Yenhliziyo
Ukucindezeleka kwe-oxidative nokuvuvukala kubonisa i-pathophysiology ye-atherosclerotic cardiovascular disease. Umsebenzi omuhle kakhulu we-antioxidant we-astaxanthin ungavimbela futhi uthuthukise i-atherosclerosis.
I-Justgood Health Triple Strength Natural I-Astaxanthin Softgels isiza ukugcina impilo yenhliziyo nemithambo yegazi ngokusebenzisa i-astaxanthin yemvelo etholakala ku-algae obomvu bothingo, izithako zayo eziyinhloko ezihlanganisa i-astaxanthin, uwoyela we-organic virgin kakhukhunathi nama-tocopherol emvelo.
6) Ukulawulwa Kwamasosha omzimba
Amaseli amasosha omzimba azwela kakhulu emonakalweni wama-radical wamahhala. I-Astaxanthin ivikela ukuzivikela kwamasosha omzimba ngokuvimbela ukulimala kwama-radical mahhala. Ucwaningo luthole ukuthi i-astaxanthin emangqamuzaneni omuntu ukukhiqiza ama-immunoglobulins, emzimbeni womuntu i-astaxanthin supplementation amasonto angu-8, amazinga e-astaxanthin egazini anda, amaseli e-T namangqamuzana e-B anda, umonakalo we-DNA uyancipha, iphrotheni esebenzayo ye-C iyancipha kakhulu.
Ama-softgel e-Astaxanthin, i-astaxanthin eluhlaza, asebenzisa ukukhanya kwelanga kwemvelo, amanzi ahlungwe nge-lava namandla elanga ukukhiqiza i-astaxanthin ehlanzekile nenempilo, engasiza ukuthuthukisa ukungatheleleki, ukuvikela umbono kanye nempilo ehlangene.
7) Yehlisa Ukukhathala
Ucwaningo lwamaviki angu-4 olungahleliwe, oluyimpumputhe oluphindwe kabili, olulawulwa yi-placebo, lwe-crossover lwezindlela ezimbili lwathola ukuthi i-astaxanthin ikhuthaze ukululama ekukhathaleni kwengqondo okubangelwa i-visual display (VDT), yehlisa amazinga aphakeme e-plasma phosphatidylcholine hydroperoxide (PCOOH) phakathi kokubili kwengqondo nangokomzimba. umsebenzi. Isizathu singase sibe umsebenzi we-antioxidant kanye nendlela yokulwa nokuvuvukala kwe-astaxanthin.
8) Ukuvikelwa kwesibindi
I-Astaxanthin inemiphumela yokuvimbela kanye ne-amelioative ezinkingeni zezempilo ezifana ne-liver fibrosis, ukulimala kwe-ischemia-reperfusion yesibindi, kanye ne-NAFLD. I-Astaxanthin ingakwazi ukulawula izindlela ezihlukahlukene zokubonisa, njengokunciphisa umsebenzi we-JNK kanye ne-ERK-1 ukuze kuthuthukiswe ukumelana ne-insulin kwesibindi, ukuvimbela inkulumo ye-PPAR-γ ukuze kuncishiswe ukuhlanganiswa kwamafutha e-hepatic, kanye ne-TGF-β1/Smad3 eyehlisa isisho ukuze kuvinjwe ukusebenza kwe-HSC kanye i-fibrosis yesibindi.
Isimo semithethonqubo ezweni ngalinye
E-China, i-astaxanthin evela emthonjeni we-rainbow algae ebomvu ingasetshenziswa njengesithako esisha sokudla ekudleni okuvamile (ngaphandle kokudla kwezingane), ngaphezu kwalokho, i-United States, iCanada neJapane nayo ivumela i-astaxanthin ukuthi isetshenziswe ekudleni .
Isikhathi sokuthumela: Dec-05-2024