I-Artemether CAS 71963-77-4 I-Artemisia Annua Extract

I-Artemether iyi-sesquiterpene lactone etholakala ezimpandeni ze-I-Artemisia annua, eyaziwa kakhulu ngokuthi i-sweet wormwood. Iwumuthi onamandla wokulwa nomalaleveva osetshenziselwa ukwelapha nokuvimbela umalaleveva. I-Artemisinin, eyandulela i-artemether, yaqala ukukhishwa kulesi sitshalo ngawo-1970, futhi ukutholakala kwayo kwatholela umcwaningi waseShayina uTu Youyou umklomelo weNobel kwezokwelapha ngo-2015.

I-Artemether isebenza ngokubhubhisa amagciwane abangela umalaleveva. Umalaleveva ubangelwa yi-protozoan parasite ebizwa ngokuthi i-Plasmodium, edluliselwa kubantu ngokulunywa omiyane besifazane abanegciwane i-Anopheles. Uma sebengaphakathi kwe-host yomuntu, amagciwane anda ngokushesha esibindini nasemaseli abomvu egazi, okubangela umkhuhlane, ukubanda, nezinye izimpawu ezifana nomkhuhlane. Uma ingelashwa, umalaleveva ungabulala.

I-Artemether iphumelela kakhulu ekulweni nezinhlobo ze-Plasmodium falciparum ezingamelani nemithi, ezibangela iningi lokufa okuhlobene nomalaleveva emhlabeni jikelele. Isebenza futhi nakwezinye izinhlobo zezinambuzane ze-Plasmodium ezibangela umalaleveva. I-Artemether ivame ukunikezwa kanye neminye imithi, njenge-lumefantrine, ukunciphisa ingozi yokumelana nemithi.

Ngaphandle kokusetshenziswa kwayo njengomuthi wokulwa nomalaleveva, i-artemether itholakale inezinye izici zokwelapha. Izifundo zikhombisile ukuthi inemisebenzi yokulwa nokuvuvukala, ukulwa nomdlavuza, kanye nokulwa namagciwane. Isetshenziswe ekwelapheni isifo samathambo, i-lupus, kanye nezinye izifo ezizimele. Iphinde yaphenywa ukuthi inamandla okwelapha i-COVID-19, yize kudingeka ucwaningo olwengeziwe ukuqinisekisa ukusebenza kwayo.

I-Artemether ngokuvamile iphephile futhi ibekezelelwa kahle uma isetshenziswa njengoba kuqondiswe. Kodwa-ke, njengazo zonke izidakamizwa, ingabangela imiphumela emibi. Imiphumela emibi evame kakhulu ye-artemether ihlanganisa isicanucanu, ukuhlanza, isiyezi, kanye nekhanda elibuhlungu. Ezimweni ezingavamile, ingabangela ukusabela okubi kakhulu, njengokushaya kwenhliziyo, ukuquleka, kanye nokulimala kwesibindi.

Ekuphetheni, i-artemether iwumuthi onamandla wokulwa nomalaleveva oshintshe kakhulu ukwelashwa nokuvimbela umalaleveva. Ukutholakala kwayo kusindise izimpilo ezingenakubalwa futhi kwathola ukuqashelwa emphakathini wesayensi. Ezinye izici zayo zokwelapha ziyenza ibe yinto ethembisayo yokwelapha ezinye izifo. Nakuba ingabangela imiphumela emibi, izinzuzo zayo zidlula kakhulu izingozi zayo uma isetshenziswa ngaphansi kokuqondisa kwezokwelapha.
Izinhlobo zomthamo ezisetshenziswa kakhulu zifaka amaphilisi, ama-capsule kanye nemijovo. Izinhlobo zemithi imithi yokulwa nomalaleveva, kanti ingxenye eyinhloko yi-artemether. Uhlamvu lwembangela yamaphilisi e-artemether kwakuyizibhebhe ezimhlophe. Uhlamvu lwe-capsule ye-artemether yi-capsule, okuqukethwe kwayo kuyimpuphu emhlophe; Uhlamvu lwemithi yomjovo we-artemether alunambala noma luphuzi olukhanyayo - njengoketshezi.